INHIBITION OF HISTONE H2B GENE-TRANSCRIPTION AND OF CELLULAR GROWTH BY A TRUNCATED VIRAL TRANSACTIVATOR PROTEIN

被引：6

作者：

DENT, CL ^{[1
]}

ESTRIDGE, JK ^{[1
]}

KEMP, LM ^{[1
]}

LATCHMAN, DS ^{[1
]}

机构：

[1] UNIV COLL & MIDDLESEX SCH MED,DEPT BIOCHEM,MED MOLEC BIOL UNIT,CLEVELAND ST,LONDON W1P 6DB,ENGLAND

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 06期

关键词：

D O I：

10.1128/MCB.10.6.3258

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The herpes simplex virus virion protein Vmw65 trans activates the viral immediate-early genes and some octamer-containing cellular genes, including that encoding histone H2B. We found, however, that a truncated form of this virion protein repressed H2B gene transcription and also dominantly inhibited induction of the gene by intact Vmw65. A cell line expressing this truncated protein expressed reduced levels of H2B and grew more slowly than the parental cell line or a similar line expressing the intact protein.

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页码：3258 / 3261

页数：4

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