AMYLOID BETA-PROTEIN PRECURSOR (APP) OF CULTURED-CELLS - SECRETORY AND NONSECRETORY FORMS OF APP

被引：24

作者：

KAMETANI, F ^{[1
]}

HAGA, S ^{[1
]}

TANAKA, K ^{[1
]}

ISHII, T ^{[1
]}

机构：

[1] PSYCHIAT RES INST TOKYO,DEPT ULTRASTRUCT,TOKYO 156,JAPAN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1990年 / 97卷 / 01期

关键词：

Amyloid deposition; Amyloid β-protein precursor;

D O I：

10.1016/0022-510X(90)90097-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Overproduction or aberrant catabolism of the predicted amyloid β-protein precursor (APP) is suspected as the cause of amyloid deposition in Alzheimer's disease and Down's syndrome brains. For possible in vitro experiments of amyloid formation, we have examined the expression of APP in various cultured cells. We found two types of APP producing cell lines. PC12h (rat pheochromocytoma) and HL-60 (human acute promyelocytic leukemia) cells produce a secretory form that is released into the culture medium, while Bu-17 (human glioma) cells synthesize only a non-secretory form that accumulates at the cell surface. APP immunoreactivity on the latter cells was detected at the tips of cell processes or growth cones. These observations indicate that the nonsecretory form of APP may play a role in cell contact or adhesion. © 1990.

引用

页码：43 / 52

页数：10

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