RECONSTITUTED VIRAL ENVELOPES - TROJAN HORSES FOR DRUG DELIVERY AND GENE-THERAPY

被引：7

作者：

BLUMENTHAL, R ^{[1
]}

LOYTER, A ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM, DEPT BIOL CHEM, JERUSALEM, ISRAEL

来源：

TRENDS IN BIOTECHNOLOGY | 1991年 / 9卷 / 02期

关键词：

D O I：

10.1016/0167-7799(91)90184-J

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Reconstituted viral envelopes (RVEs) are formed by solubilizing intact virus in detergent and reassembling the envelope on removal of detergent. RVEs can be formed in the presence of agents that become encapsulated and can then be utilized in vitro and in vivo for drug delivery, cell destruction, transfer of membrane components, and as vectors for genetic engineering. The problems with biotechnological applications of RVEs and possible strategies for overcoming them are discussed in this article.

引用

页码：41 / 45

页数：5

共 23 条

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