INTRAPERITONEAL CHEMOTHERAPY - ANALYSIS OF COMPLICATIONS WITH AN IMPLANTED SUBCUTANEOUS PORT AND CATHETER SYSTEM

被引:47
作者
DAVIDSON, SA
RUBIN, SC
MARKMAN, M
JONES, WB
HAKES, TB
REICHMAN, B
ALMADRONES, L
CHAPMAN, D
LEWIS, JL
HOSKINS, WJ
机构
[1] MEM SLOAN KETTERING CANC CTR,DEPT MED,SOLID TUMOR SERV,NEW YORK,NY 10021
[2] MEM SLOAN KETTERING CANC CTR,DEPT EPIDEMIOL & BIOSTAT,BIOSTAT SERV,NEW YORK,NY 10021
关键词
D O I
10.1016/0090-8258(91)90266-8
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
To determine the morbidity associated with delivery of intraperitoneal chemotherapy via subcutaneous semipermanent infusion catheters, we analyzed the data on 227 patients treated from April 1985 through December 1989. A total of 249 catheters were inserted and used to administer chemotherapy in these patients. There were 40 (17.6%) complications associated with the use of 230 original catheters, with 20 patients experiencing catheter inflow obstruction and 20 developing catheter-related infections; the latter group included 8 patients with bowel perforations. Although there was a trend toward an increase in catheter-related infections in association with large bowel surgery and appendectomies, sample size limited statistical analysis. There were 7 (36.8%) complications associated with the use of 19 replacement catheters. This rate was significantly increased (P = 0.03) when compared with the complication rate of original catheters. This system functions well and has an acceptable level of morbidity for delivery of intraperitoneal chemotherapy in gynecologic cancer patients. © 1991.
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页码:101 / 106
页数:6
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