SYSTEMIC CYCLOSPORINE A PROPHYLAXIS IN HIGH-RISK CORNEAL TRANSPLANTS

被引:11
作者
ROSSA, V [1 ]
SUNDMACHER, R [1 ]
HEERING, P [1 ]
机构
[1] UNIV DUSSELDORF,NEPHROL ABT,W-4000 DUSSELDORF 1,GERMANY
关键词
D O I
10.1055/s-2008-1046313
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Systemic cyclosporin A prophylaxis was applied in 18 high-risk corneal transplants. Immunoreactions occurred in three cases. They correlated with too low serum level of cyclosporin A. Two of them could be reversed by an increase of cyclosporin A dosage in combination with an intensive corticosteroid therapy. Four corneal transplants failed from persistent severe basic disease. Eleven corneal transplants remained clear during the follow-up (5-33 months). A constant trough cyclosporin A serum level of 100-120 ng/ml has been shown to exert efficient immunomodulating effects. We currently judge a postoperative prophylaxis period of 6 to 12 months with cyclosporin A to be sufficient in most high-risk cases.
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页码:466 / 469
页数:4
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