REVERSIBLE CARDIOPATHY AFTER ACCIDENTAL OVERDOSE OF MITOXANTRONE

被引：7

作者：

HACHIMIIDRISSI, S

SCHOTS, R

DEWOLF, D

VANBELLE, SJP

OTTEN, J

机构：

[1] VRIJE UNIV BRUSSELS,ACAD HOSP,DEPT HEMATOL,B-1090 BRUSSELS,BELGIUM

[2] VRIJE UNIV BRUSSELS,ACAD HOSP,DEPT MED ONCOL,B-1090 BRUSSELS,BELGIUM

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 1993年 / 10卷 / 01期

关键词：

CARDIAC TOXICITY; MITOXANTRONE OVERDOSE;

D O I：

10.3109/08880019309016526

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mitoxantrone is an anthraquinone structurally related to the anthracycline drugs doxorubicin and daunorubicin. In animal tumor models, it was equally cytotoxic as but less cardiotoxic than the parent compounds. We here describe the clinical course of a 9-year old girl who inadvertently received 100 mg/m2 of mitoxantrone as a bolus injection. Hemoperfusion carried out twice with the-objective of increasing the drug clearance was totally inefficient. Severe but transient myelotoxicity was induced. Sequential echocardiograms demonstrated a reversible decrease of the shortening fraction of the left ventricle.

引用

页码：35 / 40

页数：6

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