THYROID TRANSCRIPTION FACTOR-1 ACTIVATES THE PROMOTER OF THE THYROTROPIN RECEPTOR GENE

被引：124

作者：

CIVITAREALE, D ^{[1
]}

CASTELLI, MP ^{[1
]}

FALASCA, P ^{[1
]}

SAIARDI, A ^{[1
]}

机构：

[1] CNR,IST MED SPERIMENTALE,I-00100 ROME,ITALY

来源：

MOLECULAR ENDOCRINOLOGY | 1993年 / 7卷 / 12期

关键词：

D O I：

10.1210/me.7.12.1589

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid transcription factor 1 (TTF1), a transcription factor essential for thyroid-specific gene expression, binds to the TSHr minimal promoter. The promoter, when mutated at this binding site, shows a decreased activity in thyroid cells. In cotransfection experiments in nonthyroid cells, TTF1 is able to trans-activate the TSHr minimal promoter. This finding strengthens the importance of TTF1 in the maintenance of thyroid differentiation. The promoters of the main thyroid differentiation markers thyroglobulin, thyroperoxidase, and now TSHr, are regulated by TTF1.

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页码：1589 / 1595

页数：7

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