ULTRASOUND IN PEPTIDE-SYNTHESIS .4. RAPID CLEAVAGE OF POLYMER-BOUND PROTECTED PEPTIDES BY ALKALI AND ALKANOLAMINES

被引：8

作者：

ANURADHA, MV

RAVINDRANATH, B

机构：

[1] Vittal Mallya Scientific Research Foundation P. O. Box 406, K. R. Road

来源：

TETRAHEDRON | 1995年 / 51卷 / 19期

关键词：

D O I：

10.1016/0040-4020(95)00231-V

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Hydrolysis of polystyrene-bound protected amino acids and peptides has been achieved using dimethylaminoethanol or triethanolamine, dimethylformamide and aqueous sodium hydroxide and the reaction is accelerated by ultrasound. Rapid cleavage and excellent yields of the products in high purity, without racemization, are the main advantages of the method.

引用

页码：5675 / 5680

页数：6

共 14 条

[1]

BARANY G, 1980, PEPTIDES ANAL SYNTHE, V2, P1

[2] SOLID-PHASE SYNTHESIS OF SELECTIVELY PROTECTED PEPTIDES FOR USE AS BUILDING UNITS IN SOLID-PHASE SYNTHESIS OF LARGE MOLECULES [J].