PROTON SPECTROSCOPY IN HIV-INFECTION - RELAXATION-TIMES OF CEREBRAL METABOLITES

被引：33

作者：

WILKINSON, ID

PALEY, M

CHONG, WK

SWEENEY, BJ

SHEPHERD, JK

KENDALL, BE

HALLCRAGGS, MA

HARRISON, MJG

机构：

[1] Department of Medical Physics and Bioengineering, University College, Middlexes School of Medicine, London

[2] Department of Radiology, University College, Middlesex School of Medicine, London

[3] Reta Lila Weston Institute of Neurology, University College, Middlesex School of Medicine, London

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 06期

关键词：

MAGNETIC RESONANCE (MR); SPECTROSCOPY; ACQUIRED IMMUNODEFICIENCY SYNDROME (AIDS); HUMAN IMMUNODEFICIENCY VIRUS (HIV); T-1; T-2;

D O I：

10.1016/0730-725X(94)92036-2

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In vivo proton spectroscopy has demonstrated abnormalities in the cerebral metabolite ratios from subjects with acquired immunodeficiency syndrome (AIDS). Some of the sequences employed are subject to T-1 or T-2 weighting, which may affect spectroscopic interpretation. The relaxation times of choline (Cho), creatine (Cr), and N-acetyl (NA) resonances have been estimated at 1.5 T in 21 patients infected with the human immunodeficiency virus (HIV) and 8 controls using gradient localised, spin-echo spectroscopic sequences of varying echo and repetition times. A statistically significant increase in the T-2 of NA was found in the HIV seropositive patients who had diffuse abnormalities on MR imaging consistent with HIV encephalopathy (493 +/- 199 ms) when compared to controls (292 +/- 118 ms; p <.05). No other statistically significant differences were found in the relaxation times between patients and control subjects. These results demonstrate that signals from the NA resonance obtained using long echo time sequences in subjects who are HIV seropositive are not solely indicative of metabolite concentration.

引用

页码：951 / 957

页数：7

共 18 条

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