CHROMOSOMAL POSITION EFFECTS AND THE MODULATION OF TRANSGENE EXPRESSION

被引：96

作者：

CLARK, AJ

BISSINGER, P

BULLOCK, DW

DAMAK, S

WALLACE, R

WHITELAW, CBA

YULL, F

机构：

[1] RUAKURA RES INST,HAMILTON,NEW ZEALAND

[2] LINCOLN UNIV,CTR MOLEC BIOL,CANTERBURY,NEW ZEALAND

来源：

REPRODUCTION FERTILITY AND DEVELOPMENT | 1994年 / 6卷 / 05期

关键词：

ES CELLS;

D O I：

10.1071/RD9940589

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Chromosomal position effects can influence strongly the transcription of foreign genes in transgenic animals. This results in low frequencies and levels of gene expression and, in some cases, in aberrant patterns of expression. Strategies for overcoming these effects are described with particular reference to their application in embryonic stem cells.

引用

收藏

页码：589 / 598

页数：10

相关论文

共 49 条

[1] CHARACTERIZATION OF THE GENE ENCODING OVINE BETA-LACTOGLOBULIN - SIMILARITY TO THE GENES FOR RETINOL BINDING-PROTEIN AND OTHER SECRETORY PROTEINS [J].

ALI, S ;

CLARK, AJ .

JOURNAL OF MOLECULAR BIOLOGY, 1988, 199 (03) :415-426

[2] TRANSGENES AS PROBES FOR ACTIVE CHROMOSOMAL DOMAINS IN MOUSE DEVELOPMENT [J].

ALLEN, ND ;

CRAN, DG ;

BARTON, SC ;

HETTLE, S ;

REIK, W ;

SURANI, MA .

NATURE, 1988, 333 (6176) :852-855

[3] EXPRESSION OF A FOREIGN GENE IN A LINE OF TRANSGENIC MICE IS MODULATED BY A CHROMOSOMAL POSITION EFFECT [J].

ALSHAWI, R ;

KINNAIRD, J ;

BURKE, J ;

BISHOP, JO .

MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (03) :1192-1198

[4] HIGH-LEVEL EXPRESSION OF BIOLOGICALLY-ACTIVE HUMAN ALPHA-1-ANTITRYPSIN IN THE MILK OF TRANSGENIC MICE [J].

ARCHIBALD, AL ;

MCCLENAGHAN, M ;

HORNSEY, V ;

SIMONS, JP ;

CLARK, AJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (13) :5178-5182

[5] TISSUE SPECIFIC AND POSITION INDEPENDENT EXPRESSION OF THE COMPLETE GENE DOMAIN FOR CHICKEN LYSOZYME IN TRANSGENIC MICE [J].

BONIFER, C ;

VIDAL, M ;

GROSVELD, F ;

SIPPEL, AE .

EMBO JOURNAL, 1990, 9 (09) :2843-2848

[6] PATTERNS OF EXPRESSION OF POSITION-DEPENDENT INTEGRATED TRANSGENES IN MOUSE EMBRYO [J].

BONNEROT, C ;

GRIMBER, G ;

BRIAND, P ;

NICOLAS, JF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6331-6335

[7] MICE DEVOID OF PRP ARE RESISTANT TO SCRAPIE [J].

BUELER, H ;

AGUZZI, A ;

SAILER, A ;

GREINER, RA ;

AUTENRIED, P ;

AGUET, M ;

WEISSMANN, C .

CELL, 1993, 73 (07) :1339-1347

[8] ALTERING THE GENOME BY HOMOLOGOUS RECOMBINATION [J].

CAPECCHI, MR .

SCIENCE, 1989, 244 (4910) :1288-1292

[9] TRANSGENIC MICE CONTAINING A HUMAN HEAVY-CHAIN IMMUNOGLOBULIN GENE FRAGMENT CLONED IN A YEAST ARTIFICIAL CHROMOSOME [J].

CHOI, TK ;

HOLLENBACH, PW ;

PEARSON, BE ;

UEDA, RM ;

WEDDELL, GN ;

KURAHARA, CG ;

WOODHOUSE, CS ;

KAY, RM ;

LORING, JF .

NATURE GENETICS, 1993, 4 (02) :117-123

[10]

Clark A. J., 1992, Transgenic animals., P247

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