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IDENTIFICATION OF VIRUS COMPONENTS IN CIRCULATING IMMUNE-COMPLEXES ISOLATED DURING HEPATITIS-A VIRUS-INFECTION

被引：38
作者：
MARGOLIS, HS
NAINAN, OV
机构：
[1] Hepatitis Branch (World Health Organization Collaborating Centre for Reference and Research on Viral Hepatitis), Division of Viral Diseases, Center for Infectious Diseases, Centers for Disease Control, Atlanta, Georgia
来源：
HEPATOLOGY | 1990年 / 11卷 / 01期
关键词：
D O I：
10.1002/hep.1840110107
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Circulating immune complexes were isolated by conglutinin affinity chromatography during the course of hepatitis A virus infection in a chimpanzee. Characterization of circulating immune complexes showed that most of the hepatitis A virus‐specific antibody was IgM, that IgG was present and that C3d and fibronectin were also present. Hepatitis A virus capsid polypeptides were identified in the circulating immune complexes and polypeptides in the molecular weight range of 63 to 67 kDa having immunological determinants common to both C3d and hepatitis A virus. Hepatitis A virus‐RNA was detected in these circulating immune complexes using the polymerase chain reaction for in vitro amplification of nucleic acid and suggests the circulating immune complexes contain intact virus. Copyright © 1990 American Association for the Study of Liver Diseases
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页码：31 / 37
页数：7
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