EXPRESSION OF THE LIVER-ENRICHED TRANSCRIPTIONAL ACTIVATOR PROTEIN DBP FOLLOWS A STRINGENT CIRCADIAN-RHYTHM

被引：211

作者：

WUARIN, J

SCHIBLER, U

机构：

[1] Department of Molecular Biology University of Geneva 30 Quai Ernest Ansermet

来源：

CELL | 1990年 / 63卷 / 06期

关键词：

D O I：

10.1016/0092-8674(90)90421-A

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The liver-enriched transcriptional activator protein DBP accumulates in hepatocytes of adult rats according to a strictly controlled circadian rhythm. DBP is not detectable in liver nuclei during the morning hours. Its level raises sharply during the afternoon and reaches a maximum at about 8 p.m. During the night the cellular DBP concentration decreases below detectability. This oscillation is "free running," transcriptionally regulated, and may be under the negative control of glucocorticoid hormones. In keeping with the rhythmicity of DBP accumulation, the albumin gene, a putative target of DBP, is transcribed more efficiently in the evening than in the morning.

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页码：1257 / 1266

页数：10

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