RESIDUES OF DOXYCYCLINE AND OXYTETRACYCLINE IN EGGS AFTER MEDICATION VIA DRINKING-WATER TO LAYING HENS

被引：35

作者：

YOSHIMURA, H

OSAWA, N

RASA, FSC

HERMAWATI, D

WERDININGSIH, S

ISRIYANTHI, NMR

SUGIMORI, T

机构：

[1] National Veterinary Assay Laboratory, Tokyo, 185, 1-15-1 Tokura, Kokubunji-shi

[2] Japan Food Research Laboratories, Tokyo, 151, 52-1 Motoyoyogi-cho, Shibuya-ku

[3] Balai Pengujian Mutu dan Sertifikasi Obat Hewan (Veterinary Drug Assay Laboratory), Bogor, 16340, Gunung Sindur

[4] Japan International Cooperation Agency, Shinjuku Mitsui Bldg, Tokyo, 163, 2-1-2 Nishi-shinjuku, Shinjuku-ku

来源：

FOOD ADDITIVES AND CONTAMINANTS | 1991年 / 8卷 / 01期

关键词：

DOXYCYCLINE; OXYTETRACYCLINE; RESIDUES; EGGS;

D O I：

10.1080/02652039109373956

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Doxycycline (DOTC) and oxytetracycline (OTC) were dissolved in drinking water (0.5 g/l) and supplied to laying hens for 7 consecutive days. Eggs laid were collected daily during and after medication, and the antibiotic concentrations in the yolk and albumin were determined by the cup-plate method with Bacillus cereus var. mycoides ATCC 11778. The concentrations of both antibiotics were increased in yolk day by day with the advance in medication, reached peaks 2 days after withdrawal and then declined gradually. Mean peak concentrations in the yolk were 6.70-mu-g/g for DOTC and 1.42-mu-g/g for OTC. Peak concentrations in the albumin occurred in the middle stage of medication, where the mean values were 12.24-mu-g/g for DOTC and 1.03 mu-g/g for OTC. DOTC was detected in albumin until 24 days after withdrawal and for 2 days more in yolk than in albumin. OTC was detected in yolk until 9 days after withdrawal. The depletion period of OTC was shorter for the albumin, where the residue disappeared in all eggs 6 days after withdrawal. In spite of similarities between DOTC and OTC in structure, DOTC was deposited in higher concentrations and lasted for a longer period in eggs. This characteristic was considered due to its greater lipophilicity, closely correlated with oral absorption and tissue penetration.

引用

页码：65 / 69

页数：5

共 11 条

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