ACTIVITIES OF RIFABUTIN, CLARITHROMYCIN, AND ETHAMBUTOL AGAINST 2 VIRULENT-STRAINS OF MYCOBACTERIUM-AVIUM IN A MOUSE MODEL

被引:9
作者
FURNEY, SK [1 ]
SKINNER, PS [1 ]
FARRER, J [1 ]
ORME, IM [1 ]
机构
[1] COLORADO STATE UNIV,DEPT MICROBIOL,MYCOBACTERIOL RES LAB,FT COLLINS,CO 80523
关键词
D O I
10.1128/AAC.39.3.786
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Rifabutin, clarithromycin, and ethambutol, which were administered at concentrations similar to those used in clinical trials that are now under way, were tested for their capacities to inhibit the growth of two highly virulent isolates of Mycobacterium avium in inbred C57BL/6 mice and in vitro in a bone marrow-derived murine macrophage model. In the latter model rifabutin and clarithromycin had modest activities against strain 101 and somewhat better activities against strain 2-151. When they were tested in vivo, however, the best results, against strain 101 were seen when the three drugs were given in combination, whereas against strain 2-151 the combination therapy showed no significant improvement over that of clarithromycin given alone. It will be of interest to note to what degree the eventual outcomes of the current trials correlate with the predictions of these animal model systems.
引用
收藏
页码:786 / 789
页数:4
相关论文
共 33 条
[1]  
BELISLE JT, 1993, J BIOL CHEM, V268, P10515
[2]   MYCOBACTERIUM-AVIUM COMPLEX INFECTION AND AIDS - ADVANCES IN THEORY AND PRACTICE [J].
BENSON, CA ;
ELLNER, JJ .
CLINICAL INFECTIOUS DISEASES, 1993, 17 (01) :7-20
[3]   AZITHROMYCIN, RIFABUTIN, AND RIFAPENTINE FOR TREATMENT AND PROPHYLAXIS OF MYCOBACTERIUM-AVIUM COMPLEX IN RATS TREATED WITH CYCLOSPORINE [J].
BROWN, ST ;
EDWARDS, FF ;
BERNARD, EM ;
TONG, W ;
ARMSTRONG, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (03) :398-402
[4]   ACTIVITIES OF WIN-57273, MINOCYCLINE, CLARITHROMYCIN, AND 14-HYDROXY-CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM COMPLEX IN HUMAN MACROPHAGES [J].
COHEN, Y ;
PERRONNE, C ;
TRUFFOTPERNOT, C ;
GROSSET, J ;
VILDE, JL ;
POCIDALO, JJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1992, 36 (10) :2104-2107
[5]   ACTIVITY OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM INFECTION IN PATIENTS WITH ACQUIRED-IMMUNE-DEFICIENCY-SYNDROME - A CONTROLLED CLINICAL-TRIAL [J].
DAUTZENBERG, B ;
TRUFFOT, C ;
LEGRIS, S ;
MEYOHAS, MC ;
BERLIE, HC ;
MERCAT, A ;
CHEVRET, S ;
GROSSET, J .
AMERICAN REVIEW OF RESPIRATORY DISEASE, 1991, 144 (03) :564-569
[6]   CLINICAL-TRIALS IN MYCOBACTERIUM-AVIUM THERAPY - LESSONS TO TAKE HOME [J].
DAUTZENBERG, B .
RESEARCH IN MICROBIOLOGY, 1994, 145 (03) :197-206
[7]   MYCOBACTERIUM-AVIUM INFECTION AND AIDS - A THERAPEUTIC DILEMMA IN RAPID EVOLUTION [J].
ELLNER, JJ ;
GOLDBERGER, MJ ;
PARENTI, DM .
JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06) :1326-1335
[8]   INVITRO AND INVIVO ACTIVITIES OF CLARITHROMYCIN AGAINST MYCOBACTERIUM-AVIUM [J].
FERNANDES, PB ;
HARDY, DJ ;
MCDANIEL, D ;
HANSON, CW ;
SWANSON, RN .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (09) :1531-1534
[9]   EFFECT OF RIFABUTIN ON DISSEMINATED MYCOBACTERIUM-AVIUM INFECTIONS IN THYMECTOMIZED, CD4 T-CELL-DEFICIENT MICE [J].
FURNEY, SK ;
ROBERTS, AD ;
ORME, IM .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (09) :1629-1632
[10]   INVIVO ACTIVITY OF AMIKACIN ALONE OR IN COMBINATION WITH CLOFAZIMINE OR RIFABUTIN OR BOTH AGAINST ACUTE EXPERIMENTAL MYCOBACTERIUM-AVIUM COMPLEX INFECTIONS IN BEIGE MICE [J].
GANGADHARAM, PRJ ;
PERUMAL, VK ;
PODAPATI, NR ;
KESAVALU, L ;
ISEMAN, MD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1988, 32 (09) :1400-1403