ON THE EMPLOYMENT OF LAMBDA-CARRAGEENAN IN A MATRIX SYSTEM .2. LAMBDA-CARRAGEENAN AND HYDROXYPROPYLMETHYLCELLULOSE MIXTURES

被引：51

作者：

BONFERONI, MC

ROSSI, S

TAMAYO, M

PEDRAZ, JL

DOMINGUEZGIL, A

CARAMELLA, C

机构：

[1] UNIV PAVIA, DEPT PHARMACEUT CHEM, VIALE TARAMELLI 12, I-27100 PAVIA, ITALY

[2] UNIV SALAMANCA, DEPT PHARM & PHARMACEUT TECHNOL, E-37007 SALAMANCA, SPAIN

[3] UNIV BASQUE COUNTRY, DEPT PHARMACEUT TECHNOL, E-01007 VITORIA, SPAIN

来源：

JOURNAL OF CONTROLLED RELEASE | 1994年 / 30卷 / 02期

关键词：

LAMBDA-CARRAGEENAN; HYDROPHILIC MATRICES; HYDROXYPROPYLMETHYLCELLULOSE; SALBUTAMOL SULFATE; CHLORPHENIRAMINE MALEATE;

D O I：

10.1016/0168-3659(94)90264-X

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The suitability of lambda-carrageenan-hydroxypropylmethylcellulose (HPMC) matrices for the controlled release of two basic drugs (salbutamol sulphate and chlorpheniramine maleate) has been assessed. The influence that the amounts of the two polymers and their ratios have on drug release profiles was studied. Percentages of lambda-carrageenan as high as 40% in the matrix gave rise to good early control of drug release, resulting in release profiles close to linearity. The overall release rate was usually higher in buffer at pH 1.2 than at pH 6.8, indicating the matrix is somewhat sensitive to the dissolution medium pH. This is possibly due to the effect of medium composition on the rate of matrix erosion. By increasing the content of the more slowly erodible HPMC, differences in release rate related to the dissolution medium could sometimes be reduced.

引用

页码：175 / 182

页数：8

共 13 条

[1]

ALDERMAN D A, 1984, International Journal of Pharmaceutical Technology and Product Manufacture, V5, P1

[2] ON THE EMPLOYMENT OF LAMBDA-CARRAGEENAN IN A MATRIX SYSTEM .1. SENSITIVITY TO DISSOLUTION MEDIUM AND COMPARISON WITH NA CARBOXYMETHYLCELLULOSE AND XANTHAN GUM [J].