COMPARATIVE-STUDY OF IMMUNOMODULATORY PROPERTIES OF MURAMYL PEPTIDES ON IMMUNE-SYSTEM CELLS OF YOUNG AND OLD MICE

被引：9

作者：

DOZMOROV, IM ^{[1
]}

KUZIN, II ^{[1
]}

LUTSAN, NI ^{[1
]}

LUTSENKO, GV ^{[1
]}

PROKHOROVA, AL ^{[1
]}

SAPOZHNIKOV, AM ^{[1
]}

ANDRONOVA, TM ^{[1
]}

IVANOV, VT ^{[1
]}

机构：

[1] MM SHEMYAKIN INST BIOORGAN CHEM, PEPTIDE CHEM LAB, MOSCOW 117871, RUSSIA

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1994年 / 16卷 / 02期

关键词：

CM-culture medium; GMDP-glucosaminil-muramyl peptide; LDA-limiting dilution analysis; MDP-muramyl dipeptide; MP-muramyl peptide; TRP-T-cell replacing factor;

D O I：

10.3109/08923979409007087

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immunomodulatory effects of two synthetic muramyl peptides (MP): muramyl dipeptide and glucosaminyl- muramyl dipeptide have been compared. It was shown, that MP effects on immune response are a consequence of the alteration in T lymphocyte regulators balance. MP action on old mice immune response and lymphocyte function was stimulating only: increasing of T helper precursors frequency and IL-1 production by macrophages. In the latter both MPs acted as correctors, recovering the decreased IL-1 production by old mice macrophages to young control level.

引用

页码：149 / 163

页数：15

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