ENZYMATIC RESOLUTION OF AN ARYLPIPERIDINE DERIVATIVE UTILIZING LIPASE CATALYZED-HYDROLYSIS

被引：18

作者：

NIEDUZAK, TR

CARR, AA

机构：

[1] Merrell Dow Research Institute, Cincinnati, OH 45215

来源：

TETRAHEDRON-ASYMMETRY | 1990年 / 1卷 / 08期

关键词：

D O I：

10.1016/S0957-4166(00)80543-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Enantiospecific hydrolysis of the acetate of 1 was carried out on a multigram scale utilizing a lipase from Aspergillus niger. Both stereoisomers R-(+) and S-(-) were obtained with high enantiomeric purity (≥ 97% ee). © 1990.

引用

页码：535 / 536

页数：2

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