THE USE OF A CHELATING DERIVATIVE OF ALPHA MELANOCYTE STIMULATING HORMONE FOR THE CLINICAL IMAGING OF MALIGNANT-MELANOMA

被引：52

作者：

WRAIGHT, EP

BARD, DR

MAUGHAN, TS

KNIGHT, CG

PAGETHOMAS, DP

机构：

[1] STRANGEWAYS RES LAB,CAMBRIDGE CB1 4RN,ENGLAND

[2] UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT NUCL MED,CAMBRIDGE CB2 2QQ,ENGLAND

[3] UNIV CAMBRIDGE,ADDENBROOKES HOSP,DEPT ONCOL & RADIOTHERAPEUT,CAMBRIDGE CB2 2QQ,ENGLAND

来源：

BRITISH JOURNAL OF RADIOLOGY | 1992年 / 65卷 / 770期

关键词：

MELANOMA; ALPHA MELANOCYTE STIMULATING HORMONE; CLINICAL STUDY; TARGETING; DIAGNOSTIC IMAGING; IN-111;

D O I：

10.1259/0007-1285-65-770-112

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

A novel chelating derivative of alpha melanocyte stimulating hormone, bisMSH-DTPA, has been used for the diagnostic targeting of malignant melanoma. 15 patients were investigated of whom nine were shown by other means to have active disease at the time of the scan. Tumours were imaged in all of these nine patients. Of a total of 46 lesions over 10 mm encountered, 41 (89%) were imaged. There were no false positives and in two cases bisMSH-DTPA was instrumental in reversing diagnoses made using ultrasound. Derivatives of melanocyte stimulating hormone may be of considerable value in targeting melanomas.

引用

页码：112 / 118

页数：7

共 22 条

[1] DESIGN OF A NEW CLASS OF SUPERPOTENT CYCLIC ALPHA-MELANOTROPINS BASED ON QUENCHED DYNAMIC SIMULATIONS [J].