ASSIGNMENT OF THE BETA-SUBUNIT OF ROD PHOTORECEPTOR CGMP PHOSPHODIESTERASE GENE PDEB (HOMOLOG OF THE MOUSE-RD GENE) TO HUMAN CHROMOSOME-4P16

被引：11

作者：

BATEMAN, JB

KLISAK, I

KOJIS, T

MOHANDAS, T

SPARKES, RS

LI, TS

APPLEBURY, ML

BOWES, C

FARBER, DB

机构：

[1] UNIV CALIF LOS ANGELES,SCH MED,DEPT OPHTHALMOL,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT PEDIAT,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,SCH MED,DEPT MED,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,LOS ANGELES CTY HARBOR MED CTR,DIV MED GENET,TORRANCE,CA 90509

[5] UNIV CHICAGO,CTR VIS SCI,CHICAGO,IL 60637

来源：

GENOMICS | 1992年 / 12卷 / 03期

关键词：

D O I：

10.1016/0888-7543(92)90454-Z

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The gene encoding the β-subunit of rod photoreceptor cGMP phosphodiesterase (gene symbol PDEB, homolog of the mouse rd gene) is mapped to human chromosome 4 using somatic cell hybrids and further localized to the chromosome band 4q16 using in situ hybridization. A mutation in the mouse gene underlies the recessive trait of retinal degeneration in the rd mouse. Thus, the human homolog is a candidate for lesions causing retinal degeneration. © 1992.

引用

页码：601 / 603

页数：3

共 19 条

[1] ISOLATION OF A CANDIDATE CDNA FOR THE GENE CAUSING RETINAL DEGENERATION IN THE RD MOUSE [J].