EVALUATION OF THE EFFICACY, TOLERABILITY, AND THERAPEUTIC PROFILE OF FLUOXETINE VERSUS MIANSERIN IN THE TREATMENT OF DEPRESSIVE-DISORDERS IN THE ELDERLY

被引：24

作者：

LAPIA, S ^{[1
]}

GIORGIO, D ^{[1
]}

CIRIELLO, R ^{[1
]}

SANNINO, A ^{[1
]}

DESIMONE, L ^{[1
]}

PAOLETTI, C ^{[1
]}

COLONNA, CV ^{[1
]}

机构：

[1] VESUVIAN GERIATR OBSERVAT CTR, DIAGN & TREATMENT UNIT, DEPARTMENTAL MENTAL HLTH UNIT, NAPLES, ITALY

来源：

CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1992年 / 52卷 / 06期

关键词：

D O I：

10.1016/S0011-393X(05)80057-8

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The therapeutic effects and tolerability of fluoxetine a selective serotonin inhibitor, and mianserin in geriatric depression were compared in a randomized, double-blind trial. Analysis of the clusters of the Hamilton Depression Scale (HAMD) indicated that fluoxetine had an overall efficacy equivalent to that of mianserin but was more effective in the treatment of depressive forms with inhibition or psychomotor slowing down, in those associated with somatic anxiety, and in those characterized by anxiety, agitation, and impulsive behavior. Fluoxetine was well tolerated and had a low incidence of side effects, which might affect patient compliance. These findings suggest that the use of fluoxetine is particularly beneficial in senile depression.

引用

页码：847 / 858

页数：12

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