A 2ND PROMOTER AND ENHANCER ELEMENT WITHIN THE IMMUNOGLOBULIN HEAVY-CHAIN LOCUS

被引：36

作者：

KOTTMANN, AH ^{[1
]}

ZEVNIK, B ^{[1
]}

WELTE, M ^{[1
]}

NIELSEN, PJ ^{[1
]}

KOHLER, G ^{[1
]}

机构：

[1] MAX PLANCK INST IMMUNBIOL,D-79108 FREIBURG,GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1994年 / 24卷 / 04期

关键词：

IMMUNOGLOBULIN HEAVY CHAIN REARRANGEMENT; CIS ACTING ELEMENT; REGULATION OF REARRANGEMENT; B CELL ONTOGENY;

D O I：

10.1002/eji.1830240407

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The joining of immunoglobulin gene segments during B cell development consists of a tightly regulated series of rearrangement steps. A variety of experiments have suggested that transcription is involved in activating the locus as substrate for the V(D)J recombinase. Here, we have characterized a region located immediately upstream of the most J-proximal D element (DQ52),which contains both promoter and enhancer activities preferentially active in precursors of B cells. Interestingly, this DQ52 regulatory element is inevitably deleted in fully rearranged H chain genes. We propose that it is involved in the early activation and rearrangement events at the IgH locus.

引用

页码：817 / 821

页数：5

共 31 条

[1] COORDINATION OF IMMUNOGLOBULIN DJH TRANSCRIPTION AND D-TO-JH REARRANGEMENT BY PROMOTER-ENHANCER APPROXIMATION
ALESSANDRINI, A
DESIDERIO, SV
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (04) : 2096 - 2107
[2] MULTIPLE IMMUNOGLOBULIN HEAVY-CHAIN GENE TRANSCRIPTS IN ABELSON MURINE LEUKEMIA VIRUS-TRANSFORMED LYMPHOID-CELL LINES
ALT, FW
ROSENBERG, N
ENEA, V
SIDEN, E
BALTIMORE, D
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1982, 2 (04) : 386 - 400
[3] ORDERED REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SEGMENTS
ALT, FW
YANCOPOULOS, GD
BLACKWELL, TK
WOOD, C
THOMAS, E
BOSS, M
COFFMAN, R
ROSENBERG, N
TONEGAWA, S
BALTIMORE, D
[J]. EMBO JOURNAL, 1984, 3 (06) : 1209 - 1219
[4] A LYMPHOCYTE-SPECIFIC CELLULAR ENHANCER IS LOCATED DOWNSTREAM OF THE JOINING REGION IN IMMUNOGLOBULIN HEAVY-CHAIN GENES
BANERJI, J
OLSON, L
SCHAFFNER, W
[J]. CELL, 1983, 33 (03) : 729 - 740
[5] BRASIER AR, 1989, BIOTECHNIQUES, V7, P1116
[6] MUTATIONS OF THE INTRONIC IGH ENHANCER AND ITS FLANKING SEQUENCES DIFFERENTIALLY AFFECT ACCESSIBILITY OF THE J(H)-LOCUS
CHEN, JZ
YOUNG, F
BOTTARO, A
STEWART, V
SMITH, RK
ALT, FW
[J]. EMBO JOURNAL, 1993, 12 (12) : 4635 - 4645
[7] GENE REARRANGEMENT AND B-CELL DEVELOPMENT
CHEN, JZ
ALT, FW
[J]. CURRENT OPINION IN IMMUNOLOGY, 1993, 5 (02) : 194 - 200
[8] Gallagher S.R., 1989, CURRENT PROTOCOLS MO
[9] THE HMG DOMAIN OF LYMPHOID ENHANCER FACTOR-I BENDS DNA AND FACILITATES ASSEMBLY OF FUNCTIONAL NUCLEOPROTEIN STRUCTURES
GIESE, K
COX, J
GROSSCHEDL, R
[J]. CELL, 1992, 69 (01) : 185 - 195
[10] A HOMOLOGOUS INVITRO SYSTEM TO ANALYZE TRANSCRIPTION OF A MOUSE IMMUNOGLOBULIN-MU HEAVY-CHAIN GENE
GILLER, T
BRUNNER, L
PICK, L
BRACK, C
[J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 172 (03): : 679 - 685

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