STIMULATION OF B-LYMPHOCYTES BY LIPOPOLYSACCHARIDES FROM ANAEROBIC-BACTERIA

被引:16
作者
HOFSTAD, T [1 ]
SKAUG, N [1 ]
SVEEN, K [1 ]
机构
[1] UNIV BERGEN,GADE INST,ORAL MICROBIOL LAB,BERGEN,NORWAY
关键词
D O I
10.1093/clinids/16.Supplement_4.S200
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Lipopolysaccharides (LPSs) from anaerobic gram-negative bacteria, including those of low endotoxic activity that are isolated from Bacteroides, Prevotella, and Porphyromonas are potent inducers of DNA replication and polyclonal immunoglobulin production in murine B lymphocytes. The activation is dose-dependent and T cell-independent. Replication of DNA and production of immunoglobulins were also stimulated by lipid A and by the LPS heteropolysaccharide that were isolated by mild acid hydrolysis of the LPSs of Bacteroides fragilis and Fusobacterium nucleatum. Combinations of LPS, lipid A, and acid-degraded polysaccharide amplified the blastogenic response. Antibodies that react with the polysaccharide part of LPSs isolated from members of the Bacteroidaceae are present in healthy human serum.
引用
收藏
页码:S200 / S202
页数:3
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