PITUITARY ADENYLATE-CYCLASE ACTIVATING POLYPEPTIDE STIMULATES INSULIN RELEASE FROM THE ISOLATED PERFUSED RAT PANCREAS

被引：74

作者：

KAWAI, K ^{[1
]}

OHSE, C ^{[1
]}

WATANABE, Y ^{[1
]}

SUZUKI, S ^{[1
]}

YAMASHITA, K ^{[1
]}

OHASHI, S ^{[1
]}

机构：

[1] RES INST POLYMERS & TEXT,TSUKUBA,IBARAKI 305,JAPAN

来源：

LIFE SCIENCES | 1992年 / 50卷 / 04期

关键词：

D O I：

10.1016/0024-3205(92)90332-J

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Pituitary adenylate cyclase activating polypeptide (PACAP) is a novel hypothelamic peptide structurally related to vasoactive intestinal peptide (VIP) and glucagon like peptide-1 (7-36) amide (tGLP-1) in its N-terminal portion. Therefore, their levels of insulinotropic potency were compared using an isolated rat pancreas perfusion. It was found that 0.1 nM PACAP (1-27) amide (PACAP27) significantly stimulated insulin release under a perfusate glucose concentration of 5.5 mM, whereas 1 nM PACAP27 did not under a perfusate glucose concentration of 2.8 mM. The potency was evaluated as tGLP-1 > PACAP27 > VIP. These results indicate that PACAP is a glucagon superfamily peptide which stimulates insulin release in a glucose dependent manner.

引用

页码：257 / 261

页数：5

共 10 条

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