DECREASED STRIATAL D2-DOPAMINE RECEPTOR MESSENGER-RNA SYNTHESIS DURING AGING

被引：31

作者：

MESCO, ER

CARLSON, SG

JOSEPH, JA

ROTH, GS

机构：

[1] FRANCIS SCOTT KEY MED CTR,NIA,GERONTOL RES CTR,NATHAN W SHOCK LABS,MOLEC GENET LAB,BALTIMORE,MD 21224

[2] FRANCIS SCOTT KEY MED CTR,NIA,MOLEC & CELLULAR BIOL LAB,MOLEC PHYSIOL & GENET SECT,BALTIMORE,MD 21224

来源：

MOLECULAR BRAIN RESEARCH | 1993年 / 17卷 / 1-2期

关键词：

DOPAMINE; AGING; STRIATUM; MESSENGER RNA SYNTHESIS; DOPAMINE-D2; RECEPTOR;

D O I：

10.1016/0169-328X(93)90085-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Decreases in striatal dopamine receptors during aging are related to deficits in motor functions, and are highly correlated with the D2 receptor subtype. Some receptor loss is attributed to cell death, while the remainder is thought to be related to synthetic capacity. We discuss here our findings, for isolated rat striatal nuclei, which indicate a 50% overall decrease in the synthesis of the dopamine D2 mRNA in aged nuclei.

引用

收藏

页码：160 / 162

页数：3

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