PEPTIDE-INDUCED T-CELL TOLERANCE TO PREVENT AUTOIMMUNE DIABETES IN A TRANSGENIC MOUSE MODEL

被引：124

作者：

AICHELE, P

KYBURZ, D

OHASHI, PS

ODERMATT, B

ZINKERNAGEL, RM

HENGARTNER, H

PIRCHER, H

机构：

[1] Institute of Experimental Immunology, Department of Pathology, University of Zürich, 8091 Zürich

[2] Ontario Cancer Institute, Department of Medical Biophysics, Toronto, Ont. M4X 1K9

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 02期

关键词：

D O I：

10.1073/pnas.91.2.444

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A synthetic peptide corresponding to an immunodominant epitope of lymphocytic choriomeningitis virus glycoprotein (LCMV GP) was used to prime or to tolerize CD8(+) T cells in vivo, dependent on mode of immunization. Peptide-specific tolerance was then examined in transgenic mice expressing LCMV GP in the beta islet cells of the pancreas; these mice develop CD8(+) T-cell-mediated diabetes within 8-14 days after LCMV infection. Specific peptide-induced tolerance prevented autoimmune destruction of beta islet cells and diabetes in this transgenic mouse model.

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页码：444 / 448

页数：5

相关论文

共 36 条

[1] EXOGENOUS PEPTIDES COMPETE FOR THE PRESENTATION OF ENDOGENOUS ANTIGENS TO MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II-RESTRICTED T-CELLS [J].

ADORINI, L ;

MORENO, J ;

MOMBURG, F ;

HAMMERLING, GJ ;

GUERY, JC ;

VALLI, A ;

FUCHS, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (04) :945-948

[2] ANTIVIRAL CYTOTOXIC T-CELL RESPONSE INDUCED BY INVIVO PRIMING WITH A FREE SYNTHETIC PEPTIDE [J].

AICHELE, P ;

HENGARTNER, H ;

ZINKERNAGEL, RM ;

SCHULZ, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (05) :1815-1820

[3] QUANTIFICATION OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS WITH AN IMMUNOLOGICAL FOCUS ASSAY IN 24-WELL OR 96-WELL PLATES [J].

BATTEGAY, M ;

COOPER, S ;

ALTHAGE, A ;

BANZIGER, J ;

HENGARTNER, H ;

ZINKERNAGEL, RM .

JOURNAL OF VIROLOGICAL METHODS, 1991, 33 (1-2) :191-198

[4] STRUCTURE OF THE HUMAN CLASS-I HISTOCOMPATIBILITY ANTIGEN, HLA-A2 [J].

BJORKMAN, PJ ;

SAPER, MA ;

SAMRAOUI, B ;

BENNETT, WS ;

STROMINGER, JL ;

WILEY, DC .

NATURE, 1987, 329 (6139) :506-512

[5] A THEORY OF SELF-NONSELF DISCRIMINATION [J].

BRETSCHER, P ;

COHN, M .

SCIENCE, 1970, 169 (3950) :1042-+

[6]

Buchmeier M J, 1980, Adv Immunol, V30, P275, DOI 10.1016/S0065-2776(08)60197-2

[7] THE RELATION BETWEEN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) RESTRICTION AND THE CAPACITY OF IA TO BIND IMMUNOGENIC PEPTIDES [J].

BUUS, S ;

SETTE, A ;

COLON, SM ;

MILES, C ;

GREY, HM .

SCIENCE, 1987, 235 (4794) :1353-1358

[8] INDUCTION OF OVALBUMIN-SPECIFIC CYTO-TOXIC T-CELLS BY INVIVO PEPTIDE IMMUNIZATION [J].

CARBONE, FR ;

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (03) :603-612

[9] PEPTIDE-SPECIFIC PREVENTION OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - NEONATAL TOLERANCE INDUCED TO THE DOMINANT T-CELL DETERMINANT OF MYELIN BASIC-PROTEIN [J].

CLAYTON, JP ;

GAMMON, GM ;

ANDO, DG ;

KONO, DH ;

HOOD, L ;

SERCARZ, EE .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (05) :1681-1691

[10] ANTIGEN ANALOG MAJOR HISTOCOMPATIBILITY COMPLEXES ACT AS ANTAGONISTS OF THE T-CELL RECEPTOR [J].

DEMAGISTRIS, MT ;

ALEXANDER, J ;

COGGESHALL, M ;

ALTMAN, A ;

GAETA, FCA ;

GREY, HM ;

SETTE, A .

CELL, 1992, 68 (04) :625-634

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