IN-VITRO ASSESSMENT OF LYMPHOCYTES RESPONSE FOLLOWING REEXPOSURE TO SILICONE

被引：3

作者：

CIAPETTI, G ^{[1
]}

GRANCHI, D ^{[1
]}

STEA, S ^{[1
]}

CENNI, E ^{[1
]}

DONATI, ME ^{[1
]}

PIZZOFERRATO, A ^{[1
]}

SCHIAVON, P ^{[1
]}

GIULIANI, R ^{[1
]}

机构：

[1] USL 29,DEPT PLAST SURG,BOLOGNA,ITALY

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 1994年 / 5卷 / 9-10期

关键词：

D O I：

10.1007/BF00120346

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Currently, the use of silicone-filled devices, mainly in plastic surgery for breast reconstruction or augmentation, is being debated by the scientific community in connection with the risk to the patient. In this study the response of whole blood or isolated peripheral blood lymphocytes from patients with silicone-gel-filled breast implants was assessed in vitro, in order to verify the hypothesis of silicone material acting in vivo as a sensitizing agent. Both quantitative and qualitative changes of lymphocyte subpopulations of patients carrying silicone devices were assessed and compared with healthy subjects. Upon 24-72 h in vitro re-exposure of patients' lymphocytes to silicone extract, lymphocyte surface antigen expression was monitored by flow cytometry, and the functional response of lymphocytes was measured by radioactive tracer uptake and biochemical changes.

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页码：640 / 643

页数：4

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