P53 GENE ANALYSIS OF OVARIAN BORDERLINE TUMORS AND STAGE-I CARCINOMAS

被引：68

作者：

KUPRYJANCZYK, J

BELL, DA

DIMEO, D

BEAUCHAMP, R

THOR, AD

YANDELL, DW

机构：

[1] HARVARD UNIV,SCH MED,DEPT PATHOL,BOSTON,MA 02115

[2] MASSACHUSETTS GEN HOSP,JAMES HOMER WRIGHT PATHOL LABS,BOSTON,MA 02114

[3] HARVARD UNIV,SCH PUBL HLTH,DEPT CANC BIOL,BOSTON,MA 02115

[4] UNIV VERMONT,DEPT PATHOL,BURLINGTON,VT 05405

来源：

HUMAN PATHOLOGY | 1995年 / 26卷 / 04期

关键词：

P53; GENE; OVARY; BORDERLINE TUMORS; EARLY OVARIAN CANCER; CLONALITY;

D O I：

10.1016/0046-8177(95)90138-8

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Mutations of the p53 gene are common in human ovarian carcinomas; however, their role in the early development of ovarian cancer is unclear. Twelve ovarian borderline tumors (BTs; eight of them p53 immunopositive) and 10 stage I carcinomas (four of them p53 immunopositive) were studied for genetic alterations in the p53 gene. The study was based on single-strand conformation polymorphism (SSCP) analysis and DNA sequencing of exons 2 through 11 of the p53 gene using DNA preparations from microdissected tumors. Mutations were found in 40% of the carcinomas (including a borderline component adjacent to carcinoma in one lesion) but in none of the pure BTs. These findings suggest that p53 mutations may not be commonly associated with the borderline phenotype of ovarian epithelial tumors but may occur during malignant transformation. HUM PATHOL 26:387-392. Copyright (C) 1995 by W.B. Saunders Company

引用

页码：387 / 392

页数：6

共 29 条

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