REGULATION OF NEURITE OUTGROWTH AND SNAP-25 GENE-EXPRESSION BY THE BRN-3A TRANSCRIPTION FACTOR

被引：72

作者：

LAKIN, ND

MORRIS, PJ

THEIL, T

SATO, TN

MOROY, T

WILSON, MC

LATCHMAN, DS

机构：

[1] UNIV COLL & MIDDLESEX SCH MED, DEPT MOLEC PATHOL, MED MOLEC BIOL UNIT, LONDON W1P 6DB, ENGLAND

[2] UNIV MARBURG, INST MOLEK BIOL & TUMORFORSCH, D-35037 MARBURG, GERMANY

[3] Scripps Res Inst, DEPT NEUROPHARMACOL, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1995年 / 270卷 / 26期

关键词：

D O I：

10.1074/jbc.270.26.15858

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

SNAP-25 is a presynaptic nerve terminal protein which is also essential for the process of neurite outgrowth in vivo and in vitro. However the processes regulating its expression have not been characterized previously. We show that the gene encoding this protein, SNAP, is strongly activated by the Brn-3a POU (Pit-Oct-Unc) family transcription factor. Expression of both Brn-3a and SNAP-25 increases when ND7 neuronal cells are induced to extend neurite processes by serum removal. Inhibition of Brn-3a expression in these cells inhibits SNAP-25 expression and abolishes the neurite outgrowth that normally occurs in response to serum removal. These results identify Brn-3a as the first transcription factor having a role in process outgrowth in neuronal cells acting, at least in part, via the activation of SNAP-25 gene expression.

引用

页码：15858 / 15863

页数：6

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