BORONATION OF ANTIBODIES WITH MERCAPTOUNDECAHYDRO-CLOSO-DODECABORATE(2-) ANION FOR POTENTIAL USE IN BORON NEUTRON-CAPTURE THERAPY

被引：21

作者：

ALAM, F ^{[1
]}

SOLOWAY, AH ^{[1
]}

BARTH, RF ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT PATHOL,COLUMBUS,OH 43210

来源：

APPLIED RADIATION AND ISOTOPES | 1987年 / 38卷 / 07期

关键词：

BIOMEDICAL ENGINEERING - Patient Treatment - BORON - Isotopes;

D O I：

10.1016/0883-2889(87)90195-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The anionic polyhedral borane derivative, mercaptoundecahydro-closo-dodecaborate (2-), has been evaluated as a boronating agent for antibodies. The objective of these studies was the selective delivery of boron to neoplasms for neutron capture therapy. Incubation of a large excess of this anion with the polyclonal antibody antithymocyte globulin (ATG) resulted in the incorporation of 9-13 mol of the anion per mol of antibody. The extent of boron incorporation into the protein was measured either by tritium-labeled B//1//2H//1//1SH**2** minus or by direct boron determination with neutron activation analysis.

引用

页码：503 / 506

页数：4

共 12 条

[1] CURRENT STATUS OF B-10-NEUTRON CAPTURE THERAPY - ENHANCEMENT OF TUMOR DOSE VIA BEAM FILTRATION AND DOSE-RATE, AND THE EFFECTS OF THESE PARAMETERS ON MINIMUM BORON CONTENT - A THEORETICAL EVALUATION [J].