LOSS OF INHIBITION IN THE CA1 REGION OF THE KAINIC ACID LESIONED HIPPOCAMPUS IS NOT ASSOCIATED WITH CHANGES IN POSTSYNAPTIC RESPONSES TO GABA

被引：39

作者：

ASHWOOD, TJ

WHEAL, HV

机构：

来源：

BRAIN RESEARCH | 1986年 / 367卷 / 1-2期

关键词：

D O I：

10.1016/0006-8993(86)91625-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Somatic and dendritic responses to .gamma.-aminobutyric acid (GABA) were recorded intracellularly from CA1 pyramidal cells in slices of the hippocampus ipsilateral and contralateral to a unilateral kainic acid lesion of the CA3 region. Ipsilateral CA1 cells show a loss of GABA-mediated synaptic inhibition. However, somatic GABA responses and the sensitivity of cells to GABA were very similar in ipsilateral and contralateral cells. This was also true for dendritic applications of GABA.

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页码：390 / 394

页数：5

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