AUTOANTIBODIES AND PREGNANCY WASTAGE

被引:16
作者
COWCHOCK, S [1 ]
机构
[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT OBSTET & GYNECOL,PHILADELPHIA,PA 19107
来源
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 1991年 / 26卷 / 01期
关键词
AUTOANTIBODIES; ANTINUCLEAR ANTIBODIES; RECURRENT ABORTION; VASCULAR DISORDERS;
D O I
10.1111/j.1600-0897.1991.tb00700.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The established association between a relatively specific group of autoantibodies binding negatively charged phospholipids and poor pregnancy outcome has advanced treatment options for women with this diagnosis. Evidence for an association between systemic autoimmune disorders and otherwise unexplained obstetric complications, in the absence of a documented antiphospholipid antibody(s), is reviewed. The existence of autoantibodies with other specificities that could be related to fetal wastage has been suggested by associations between poor obstetric histories and nonspecific serologic abnormalities observed in women with no clinical signs of an autoimmune disorder. Because signs and symptoms of vasospasm such as Raynaud's phenomenon or placental infarction have been observed in women with a history of unexplained fetal demise, a search for autoantibodies recognizing antigens common to trophoblastic and vascular cell surfaces is suggested.
引用
收藏
页码:38 / 41
页数:4
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