SUSTAINED ACTIVATION DOES NOT DESENSITIZE THE DOPAMINE D2-RECEPTOR-MEDIATED CONTROL OF EVOKED INVITRO RELEASE OF RADIOLABELED ACETYLCHOLINE FROM RAT STRIATUM

被引：9

作者：

DRUKARCH, B

SCHEPENS, E

STOOF, JC

机构：

[1] Department of Neurology, Medical Faculty, Free University, 1081 BT Amsterdam

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 196卷 / 02期

关键词：

DOPAMINE D2-RECEPTORS; ACETYLCHOLINE RELEASE; RECEPTOR DESENSITIZATION; RECEPTOR REGULATION; STRIATUM;

D O I：

10.1016/0014-2999(91)90431-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Striatal acetylcholine release is decreased on activation of D2 dopamine receptors. In the present study, it was investigated whether sustained activation of these receptors would reduce their capacity to mediate this effect. It was shown that activation for up to 2 h with high concentrations of either the endogeneous ligand, dopamine, or the selective D2 receptor agonist, LY 171555, did not induce desensitization of the D2 receptor-mediated inhibited of electrically evoked [H-3]acetylcholine release from rat striatal tissue slices.

引用

收藏

页码：209 / 212

页数：4

相关论文

共 10 条

[1] CLONING AND EXPRESSION OF A RAT D2 DOPAMINE RECEPTOR CDNA [J].

BUNZOW, JR ;

VANTOL, HHM ;

GRANDY, DK ;

ALBERT, P ;

SALON, J ;

CHRISTIE, MJ ;

MACHIDA, CA ;

NEVE, KA ;

CIVELLI, O .

NATURE, 1988, 336 (6201) :783-787

[2] LACK OF A DOPAMINE AUTORECEPTOR SELECTIVE PROFILE OF B-HT 920 IN FUNCTIONAL INVITRO MODEL SYSTEMS OF D2-RECEPTORS IN RAT STRIATUM [J].

DRUKARCH, B ;

SCHEPENS, E ;

DOLLEMANVANDERWEEL, MJ ;

DEBOER, P ;

VANVLIET, BJ ;

STOOF, JC .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 187 (02) :257-269

[3] STIMULATION OF D-2 DOPAMINE-RECEPTORS DECREASES THE EVOKED INVITRO RELEASE OF [H-3]ACETYLCHOLINE FROM RAT NEOSTRIATUM - ROLE OF K+ AND CA-2+ [J].

DRUKARCH, B ;

SCHEPENS, E ;

SCHOFFELMEER, ANM ;

STOOF, JC .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (06) :1680-1685

[4] EFFECTS OF DOPAMINERGIC RECEPTOR AGONISTS AND ANTAGONISTS ON ACTIVITY OF NEO-STRIATAL CHOLINERGIC SYSTEM [J].

GUYENET, PG ;

AGID, Y ;

JAVOY, F ;

BEAUJOUAN, JC ;

ROSSIER, J ;

GLOWINSKI, J .

BRAIN RESEARCH, 1975, 84 (02) :227-244

[5] REGULATION OF STRIATAL ACETYLCHOLINE-RELEASE BY DOPAMINE AFTER NIGROSTRIATAL BUNDLE INJURY [J].

JACKSON, D ;

ZIGMOND, MJ .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1990, 604 :606-608

[6] CHRONIC PHARMACOLOGICAL MANIPULATION OF DOPAMINE-RECEPTORS IN BRAIN [J].

JENNER, P ;

MARSDEN, CD .

NEUROPHARMACOLOGY, 1987, 26 (7B) :931-940

[7] ROLE OF PHOSPHORYLATION IN DESENSITIZATION OF THE BETA-ADRENOCEPTOR [J].

LEFKOWITZ, RJ ;

HAUSDORFF, WP ;

CARON, MG .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1990, 11 (05) :190-194

[8] THE STRIATAL CHOLINERGIC INTERNEURON - SYNAPTIC TARGET OF DOPAMINERGIC TERMINALS [J].

LEHMANN, J ;

LANGER, SZ .

NEUROSCIENCE, 1983, 10 (04) :1105-1120

[9] AGONIST-INDUCED SUBSENSITIVITY OF ADENYLATE-CYCLASE COUPLED WITH A DOPAMINE RECEPTOR IN SLICES FROM RAT CORPUS STRIATUM [J].

MEMO, M ;

LOVENBERG, W ;

HANBAUER, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (14) :4456-4460

[10]

STOOF JC, 1988, PROGR CATHECOLAMIN B, V42, P47