CHOX-E, A CHICKEN HOMEOGENE OF THE H2.0 TYPE EXHIBITS DORSOVENTRAL RESTRICTION IN THE PROLIFERATING REGION OF THE SPINAL-CORD

被引:28
作者
RANGINI, Z
BENYEHUDA, A
SHAPIRA, E
GRUENBAUM, Y
FAINSOD, A
机构
[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT CELLULAR BIOCHEM,IL-91010 JERUSALEM,ISRAEL
[2] HEBREW UNIV JERUSALEM,DEPT GENET,IL-91904 JERUSALEM,ISRAEL
关键词
HOMEOBOX; EMBRYONIC DEVELOPMENT; CHICKEN; CENTRAL NERVOUS SYSTEM; RHOMBOMERES;
D O I
10.1016/0925-4773(91)90037-7
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
CHox E is a novel chicken homeogene that belongs to the H2.0 family of homeodomains. Its homeobox sequence is interrupted by an intron between amino acids 44 and 45. Expression of CHox E during embryogenesis is localized to the central nervous system. The anterior boundary of CHox E expression can initially be localized to rhombomere number 1, later in development this boundary reaches up to the rhombencephalic isthmus. CHox E expression in the spinal cord localizes dorso-ventrally to the dorsal half of the basal plate. CHox E expression is always restricted to the proliferating region, the ventricular zone. As the ventricular zone becomes restricted laterally, so does the CHox E expressing region. Once this region of the ventricular zone ceases to exist, CHox E specific transcripts become undetectable. The site and time of CHox E expression suggest a very early function in the differentiation of the cells derived from that region of the ventricular zone.
引用
收藏
页码:13 / 24
页数:12
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