INDOMETHACIN AND POSTPRANDIAL GALLBLADDER EMPTYING

被引:39
作者
ODONNELL, LJD
WILSON, P
GUEST, P
CATNACH, SM
MCLEAN, A
WICKHAM, JEA
FAIRCLOUGH, PD
机构
[1] ST BARTHOLOMEWS HOSP,DEPT RADIOL,LONDON EC1A 7BE,ENGLAND
[2] ST PETERS HOSP,INST UROL,LONDON WC2A 2EX,ENGLAND
关键词
D O I
10.1016/0140-6736(92)91333-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Patients with gallstone disease commonly have impaired gallbladder emptying. To see whether non-steroidal anti-inflammatory drugs (NSAIDs) prevent gallstone formation by improving gallbladder emptying, we assessed the effect of indomethacin on postprandial emptying in healthy subjects and in patients with gallstone disease. Subjects received indomethacin 25 mg three times a day for a week and matching placebo for another week. Compared with placebo, indomethacin improved postprandial gallbladder emptying in all 7 patients with gallstone disease. This finding was not recorded in healthy subjects with normal gallbladders. The prevention of gallstone formation associated with ingestion of NSAIDs may be due mainly to a prokinetic effect on the gallbladder since there is no evidence to suggest that these drugs affect cholesterol crystal nucleation at ordinary therapeutic doses in man or animals.
引用
收藏
页码:269 / 271
页数:3
相关论文
共 10 条
[1]   EFFECT OF DIETARY-CHOLESTEROL AND INDOMETHACIN ON CHOLELITHIASIS AND GALLBLADDER MOTILITY IN GUINEA-PIG [J].
BROTSCHI, EA ;
LAMORTE, WW ;
WILLIAMS, LF .
DIGESTIVE DISEASES AND SCIENCES, 1984, 29 (11) :1050-1056
[2]   SONOGRAPHIC MEASUREMENT OF GALLBLADDER VOLUME [J].
DODDS, WJ ;
GROH, WJ ;
DARWEESH, RMA ;
LAWSON, TL ;
KISHK, SMA ;
KERN, MK .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1985, 145 (05) :1009-1011
[3]  
HOOD K, 1988, LANCET, V2, P1233
[4]  
LAMORTE WW, 1985, SURGERY, V98, P445
[5]   ASPIRIN PREVENTION OF CHOLESTEROL GALLSTONE FORMATION IN PRAIRIE DOGS [J].
LEE, SP ;
CAREY, MC ;
LAMONT, JT .
SCIENCE, 1981, 211 (4489) :1429-1431
[6]   RECURRENCE AND RE-RECURRENCE OF GALL-STONES AFTER MEDICAL DISSOLUTION - A LONGTERM FOLLOW UP [J].
ODONNELL, LDJ ;
HEATON, KW .
GUT, 1988, 29 (05) :655-658
[7]   INHIBITION OF PROSTAGLANDIN SYNTHESIS FAILS TO PREVENT GALLBLADDER MUCIN HYPERSECRETION IN THE CHOLESTEROL-FED PRAIRIE DOG [J].
OLEARY, DP ;
LAMORTE, WW ;
SCOTT, TE ;
BOOKER, ML ;
STEVENSON, J .
GASTROENTEROLOGY, 1991, 101 (03) :812-820
[8]   EFFECT OF AGE AND SENSITIVITY TO CHOLECYSTOKININ ON GALLSTONE FORMATION IN THE GUINEA-PIG [J].
POSTON, GJ ;
DRAVIAM, EJ ;
YAO, CZ ;
TOWNSEND, CM ;
THOMPSON, JC .
GASTROENTEROLOGY, 1990, 98 (04) :993-999
[9]  
RHODES M, 1991, Gastroenterology, V100, pA337
[10]   CONTRACTION OF GUINEA-PIG GALLBLADDER STRIPS BY LEUKOTRIENES AND OTHER AGONISTS [J].
YUSKO, P ;
HALL, RA ;
FORDHUTCHINSON, AW .
PROSTAGLANDINS, 1983, 25 (03) :397-403