AN IMPROVED METHOD FOR CHIRAL OXAZABOROLIDINE-CATALYZED REDUCTION OF 4-CHROMANONE ANALOGS AND MK-0499

被引：28

作者：

SHI, YJ

CAI, DW

DOLLING, UH

DOUGLAS, AW

TSCHAEN, DM

VERHOEVEN, TR

机构：

[1] Department of Process Research, Merck Research Laboratory, Rahway, NJ 07065

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 35期

关键词：

D O I：

10.1016/S0040-4039(00)78232-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Addition of isopropanol to the stoichiometric reduction of ketones 4-8 using oxazborolidine-borane complex 3 or the oxazaborolidine-catalyzed reduction of 4-chromanone analogs (1, 7-9) enhances the enantioselectivity of the reduction.

引用

页码：6409 / 6412

页数：4

共 16 条

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