TRANSFORMATION OF CHRONIC MYELOMONOCYTIC LEUKEMIA TO ACUTE LYMPHOBLASTIC-LEUKEMIA - CASE-REPORT AND REVIEW OF THE LITERATURE OF LYMPHOBLASTIC TRANSFORMATION OF MYELODYSPLASTIC SYNDROME

被引：32

作者：

KOUIDES, PA ^{[1
]}

BENNETT, JM ^{[1
]}

机构：

[1] UNIV ROCHESTER, MED CTR, MED ONCOL UNIT, ROCHESTER, NY 14642 USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1995年 / 49卷 / 02期

关键词：

MYELODYSPLASTIC SYNDROME; CHRONIC MYELOMONOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA;

D O I：

10.1002/ajh.2830490211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

If chronic myelomonocytic leukemia (CMML) transforms into an acute leukemic phase, the blast crisis is invariably myeloid, Occasionally, the other subtypes of myelodysplastic syndrome (MDS) (refractory anemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation) have been noted to transform into acute lymphoblastic leukemia (ALL). We now report a case of CMML that transformed into ALL and we review the literature of 13 other cases of MDS with ALL transformation. Such cases provide suggestive clinical evidence that MDS can involve a pluripotent stem cell. (C) 1995 Wiley-Liss, Inc.

引用

页码：157 / 162

页数：6

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