DETECTION OF ALPHA/BETA-HYDROLASE FOLD IN THE CELL-SURFACE ESTERASES OF ACINETOBACTER SPECIES USING AN ANALYSIS OF 3D PROFILES

被引：6

作者：

ALON, RN

MIRNY, L

SUSSMAN, JL

GUTNICK, DL

机构：

[1] TEL AVIV UNIV,GEORGE S WISE FAC LIFE SCI,DEPT MOLEC MICROBIOL & BIOTECHNOL,IL-69978 RAMAT AVIV,ISRAEL

[2] WEIZMANN INST SCI,DEPT BIOL STRUCT,IL-76100 REHOVOT,ISRAEL

[3] BROOKHAVEN NATL LAB,DEPT BIOL,UPTON,NY 11973

[4] BROOKHAVEN NATL LAB,DEPT CHEM,UPTON,NY 11973

来源：

FEBS LETTERS | 1995年 / 371卷 / 03期

关键词：

ACINETOBACTER; ESTERASE; ALPHA/BETA HYDROLASE FOLD; STRUCTURAL ALIGNMENT;

D O I：

10.1016/0014-5793(95)00861-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The primary sequence of esterases from Acinetobacter lwoffii RAG-1 and A. calcoaceticus BD413 were compared with linearized structural sequences of two hundred proteins selected from Brookhaven Protein DataBank using a modified version of the Bowie et al, algorithm [3]. Significant structural homology was found to alpha/beta proteins and specifically to those with the alpha/beta-hydrolase fold for,which the crystal structure was reported. No such homology was detected using common primary sequence alignment programs such as FASTA or BLAST.

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页码：231 / 235

页数：5

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