TERATOGENIC POTENTIAL OF CORTICOSTEROIDS IN HUMANS

被引:99
作者
FRASER, FC [1 ]
SAJOO, A [1 ]
机构
[1] MCGILL UNIV,DEPT BIOL,MONTREAL,PQ H3A 1B1,CANADA
关键词
D O I
10.1002/tera.1420510107
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The literature was surveyed in an attempt to assess whether corticosteroids have a detectable teratogenic effect. Reporting bias was illustrated by the fact that the frequency of malformations in offspring of women treated with corticosteroids was much higher in reports of single cases than in reports of series of cases. In the latter group there were 468 exposed women, and the frequency of malformations was 3.5%, no different from the usual population frequency. There were, however, 2 cases of cleft palate, whereas 0.2 cases would be expected; it is impossible to tell whether this is a real increase. We conclude that the teratogenic potential of corticosteroids is so low as to be undetectable from the data available. (C) 1995 Wiley-Liss, Inc.
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页码:45 / 46
页数:2
相关论文
共 11 条
[1]  
BONGIOVANNI AM, 1960, FERTIL STERIL, V11, P181
[2]  
DOIG RK, 1956, LANCET, V2, P730
[3]  
FRASER F C, 1959, N Y State J Med, V59, P1597
[4]  
FRASER FC, 1951, PEDIATRICS, V8, P527
[5]  
FRASER FC, 1964, 2 INT C CONG MALF, P277
[6]  
HARRIS JWS, 1956, LANCET, V1, P1045
[7]   PREDNISONE DOES NOT PREVENT RECURRENT FETAL DEATH IN WOMEN WITH ANTIPHOSPHOLIPID ANTIBODY [J].
LOCKSHIN, MD ;
DRUZIN, ML ;
QAMAR, T .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 160 (02) :439-443
[8]  
POPERT HH, 1962, BRIT MED J, V1, P967
[9]   PRENATAL EXPOSURE TO PREDNISONE IN HUMANS AND ANIMALS RETARDS INTRA-UTERINE GROWTH [J].
REINISCH, JM ;
SIMON, NG ;
KAROW, WG ;
GANDELMAN, R .
SCIENCE, 1978, 202 (4366) :436-438
[10]   CORTICOSTEROID-THERAPY FOR PREGNANT ASTHMATIC PATIENT [J].
SCHATZ, M ;
PATTERSON, R ;
ZEITZ, S ;
OROURKE, J ;
MELAM, H .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1975, 233 (07) :804-807