SHEEP LINKAGE MAPPING - RFLP MARKERS FOR COMPARATIVE MAPPING STUDIES

被引：8

作者：

MONTGOMERY, GW

PENTY, JM

HENRY, HM

SISE, JA

LORD, EA

DODDS, KG

HILL, DF

机构：

[1] UNIV OTAGO, CTR GENE RES, DUNEDIN, NEW ZEALAND

[2] AGRES, INVERMAY AGR CTR, MOSGIEL, NEW ZEALAND

来源：

ANIMAL GENETICS | 1995年 / 26卷 / 04期

关键词：

FN1; INHA; LINKAGE; OVINE; RFLP; SHEEP;

D O I：

10.1111/j.1365-2052.1995.tb03252.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Restriction fragment length polymorphisms (RFLPs) detected using cDNA probes for conserved genes provide an important set of markers that anchor or link syntenic groups in a range of divergent mammalian species. DNA probes from sheep, cattle, pig, human and mouse were screened against sheep DNA samples and 24 new RFLP markers for sheep were identified. Among the loci tested, 22 had a homologue that has been mapped in humans. An RFLP for fibronectin (FN1) was linked to alpha-inhibin (INHA) at a distance of 5cM. The FN1 locus has been assigned to sheep chromosome 2q41-q44 and linkage between FN1 and INHA assigns INHA to the same chromosome in sheep. In addition to the new loci reported here, 28 RFLPs have been published previously by this group and these are collated together with RFLPs published from other laboratories. RFLPs have been reported for 86 loci in sheep. Fifty-four loci have been mapped to 16 different chromosomes.

引用

页码：249 / 259

页数：11

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