VARIANCE IMPUTATION FOR OVERVIEWS OF CLINICAL-TRIALS WITH CONTINUOUS RESPONSE

被引：1031

作者：

FOLLMANN, D

ELLIOTT, P

SUH, I

CUTLER, J

机构：

[1] YONSEI UNIV, DEPT PREVENT MED & PUBL HLTH, SEOUL, SOUTH KOREA

[2] UNIV LONDON LONDON SCH HYG & TROP MED, DEPT PUBL HLTH & POLICY, LONDON WC1E 7HT, ENGLAND

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 1992年 / 45卷 / 07期

基金：

美国国家卫生研究院;

关键词：

CROSSOVER; METAANALYSIS; PARALLEL GROUPS; PRETEST POSTTEST;

D O I：

10.1016/0895-4356(92)90054-Q

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Overviews of clinical trials are an efficient and important means of summarizing information about aa particular scientific area. When the outcome is aa continuous variable, both treatment effect and variance estimates are required to construct aa confidence interval for the overall treatment effect. Often, only partial information about the variance is provided in the publication of the clinical trial. This paper provides heuristic suggestions for variance imputation based on partial variance information. Both pretest-posttest (parallel groups) and crossover designs are considered. AA key idea is to use separate sources of incomplete information to help choose aa better variance estimate. The imputation suggestions are illustrated with aa data set.

引用

页码：769 / 773

页数：5

共 8 条

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