METAL-COMPLEXES OF RADIOSENSITIZATION DRUGS - THE CHARACTERIZATION OF THE METRONIDAZOLE ADDUCTS OF DIRHODIUM(II)TETRACARBOXYLATE COMPOUNDS

被引：21

作者：

DYSON, TM

MORRISON, EC

TOCHER, DA

DALE, LD

EDWARDS, DI

机构：

[1] UNIV LONDON UNIV COLL,DEPT CHEM,20 GORDON ST,LONDON WC1H 0AJ,ENGLAND

[2] POLYTECH E LONDON,CHEMOTHERAPY RES UNIT,LONDON E15 4LZ,ENGLAND

来源：

INORGANICA CHIMICA ACTA | 1990年 / 169卷 / 01期

关键词：

D O I：

10.1016/S0020-1693(00)82045-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The compounds Rh2(O2CR)4·2metronidazole (R = CH3 (1); CH2CH2CH2Ph (2)) have been prepared by the reaction of Rh2(O2CR)4 with an excess of metronidazole. The compounds have been characterized by analytical, spectroscopic, electrochemical and crystallographic measurements. Preliminary biological studies, on 1, have shown the compound to have selective toxic effects on DNA and intact cells under both anoxic and hypoxic conditions. © 1990.

引用

页码：127 / 131

页数：5

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