SPECIFIC INHIBITORS IN VITAMIN BIOSYNTHESIS .7. SYNTHESES OF BLOCKED 7,8-DIHYDROPTERIDINES VIA ALPHA-AMINO KETONES

被引：36

作者：

ALHASSAN, SS ^{[1
]}

CAMERON, RJ ^{[1
]}

CURRAN, AWC ^{[1
]}

LYALL, WJS ^{[1
]}

NICHOLSON, SH ^{[1
]}

ROBINSON, DR ^{[1
]}

STUART, A ^{[1
]}

SUCKLING, CJ ^{[1
]}

STIRLING, I ^{[1
]}

WOOD, HCS ^{[1
]}

机构：

[1] UNIV STRATHCLYDE, DEPT PURE & APPL CHEM, 295 CATHEDRAL ST, GLASGOW G1 1XL, SCOTLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1985年 / 08期

关键词：

D O I：

10.1039/p19850001645

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of 15 blocked 7,8-dihydropteridines is described in which the pyrazine ring is built from a derivative of an .alpha.-aminoketone. Three routes to the amino ketones abased upon amino acids, nitrosylchloride addition to alkenes, and nitro alcohols are discussed. The compounds synthesized are inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase, an enzyme in the pathway leading to dihydrofolate, and the inhibitory potencies of the compounds are discussed in the light of a hypothetical active site model for the enzyme.

引用

页码：1645 / 1659

页数：15

共 28 条

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