CONFORMATIONALLY RESTRICTED INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME - SYNTHESIS AND COMPUTATIONS

被引:106
作者
THORSETT, ED
HARRIS, EE
ASTER, SD
PETERSON, ER
SNYDER, JP
SPRINGER, JP
HIRSHFIELD, J
TRISTRAM, EW
PATCHETT, AA
ULM, EH
VASSIL, TC
机构
[1] MERCK SHARP & DOHME RES LABS,RAHWAY,NJ 07065
[2] MERCK INST THERAPEUT RES,W POINT,PA 19486
关键词
D O I
10.1021/jm00152a014
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:251 / 260
页数:10
相关论文
共 61 条
[1]   CONFORMATIONAL-ANALYSIS .130. MM2 - HYDROCARBON FORCE-FIELD UTILIZING V1 AND V2 TORSIONAL TERMS [J].
ALLINGER, NL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1977, 99 (25) :8127-8134
[2]   CONFORMATIONAL-ANALYSIS AND ACTIVE-SITE MODELING OF ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS [J].
ANDREWS, PR ;
CARSON, JM ;
CASELLI, A ;
SPARK, MJ ;
WOODS, R .
JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (03) :393-399
[3]  
BEYERS LD, 1973, BIOCHEMISTRY-US, V12, P2070
[4]   NMR INVESTIGATIONS ON ALANYL-[15-PERCENT C-13, 95-PERCENT PROLINE-N-15 - N-15 CHEMICAL-SHIFTS AND C-13-N-15 COUPLING-CONSTANTS [J].
BLOMBERG, F ;
RUTERJANS, H ;
LINTNER, K ;
TOMA, F ;
FERMANDJIAN, S .
ORGANIC MAGNETIC RESONANCE, 1978, 11 (12) :598-602
[5]   CYANOHYDRIDOBORATE ANION AS A SELECTIVE REDUCING AGENT [J].
BORCH, RF ;
BERNSTEIN, MD ;
DURST, HD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1971, 93 (12) :2897-+
[6]   EINE EINFACHE SYNTHESE VON L-LYSIN [J].
BRENNER, M ;
RICKENBACHER, HR .
HELVETICA CHIMICA ACTA, 1958, 41 (01) :181-188
[7]  
BULL HB, UNPUB
[8]   ANGIOTENSIN-CONVERTING ENZYME-INHIBITORS - IMPORTANCE OF THE AMIDE CARBONYL OF MERCAPTOACYL AMINO-ACIDS FOR HYDROGEN-BONDING TO THE ENZYME [J].
CONDON, ME ;
PETRILLO, EW ;
RYONO, DE ;
REID, JA ;
NEUBECK, R ;
PUAR, M ;
HEILKES, JE ;
SABO, EF ;
LOSEE, KA ;
CUSHMAN, DW ;
ONDETTI, MA .
JOURNAL OF MEDICINAL CHEMISTRY, 1982, 25 (03) :250-258
[9]  
Cushman D., 1981, ANGIOTENSIN CONVERTI, P3
[10]  
Cushman D W, 1980, Prog Med Chem, V17, P41, DOI 10.1016/S0079-6468(08)70157-7