HUMAN ODOR INTENSITY PERCEPTION - CORRELATION WITH FROG EPITHELIAL ADENYLATE-CYCLASE ACTIVITY AND TRANSEPITHELIAL VOLTAGE RESPONSE

被引:15
作者
DOTY, RL
KREISS, DS
FRYE, RE
机构
[1] UNIV PENN,SCH MED,DAVID MAHONEY INST NEUROL SCI,PHILADELPHIA,PA 19104
[2] UNIV PENN,SCH MED,DEPT OTORHINOLARYNGOL & HUMAN COMMUN,PHILADELPHIA,PA 19104
关键词
Adenylate cyclase; Cyclic adenosine 3′; 5′-monophosphate; Electro-olfactogram; Multidimensional scaling; Odor perception; Olfactory epithelium; Psychophysics;
D O I
10.1016/0006-8993(90)91070-W
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Although a number of odorants are hypothesized to depolarize frog olfactory receptor cells by binding to ciliary glycoproteins which activate membrane-bound G-proteins to induce adenylate cyclase-mediated increases in intracellular cAMP (cyclic adenosine 3′,5′-monophosphate), it is not known whether these odorants influence human odor perception via similar mechanisms. In this paper we present evidence derived from odor attribute ranking and multidimensional scaling procedures that the perceived intensity of such odorants to humans is correlated with (a) the amount of adenylate cyclase activity they induce in an in vitro frog olfactory cilia preparation and (b) the magnitude of their influence on the frog transepithelial voltage response or electro-olfactogram (EOG). These observations are in accord with the hypothesis that the perception of the intensity of some odors by humans is associated with cAMP-related epithelial processes and imply that remarkable homologies exist between the intensity-related olfactory receptor mechanisms of frog and man. © 1990.
引用
收藏
页码:130 / 134
页数:5
相关论文
共 40 条
[1]  
AMOORE JE, 1971, HDB SENSORY PHYSIO 1, V4, P245
[2]  
BEETS MGJ, 1970, PHARMACOL REV, V22, P1
[3]  
BRUCH RC, 1987, NY ACAD SCI, V110, P205
[4]   ANALYSIS OF INDIVIDUAL DIFFERENCES IN MULTIDIMENSIONAL SCALING VIA AN N-WAY GENERALIZATION OF ECKART-YOUNG DECOMPOSITION [J].
CARROLL, JD ;
CHANG, JJ .
PSYCHOMETRIKA, 1970, 35 (03) :283-&
[5]  
DAVIES JT, 1971, HDB SENSORY PHYSL, V4, P323
[6]   INTRANASAL TRIGEMINAL STIMULATION FROM ODOROUS VOLATILES - PSYCHOMETRIC RESPONSES FROM ANOSMIC AND NORMAL HUMANS [J].
DOTY, RL ;
BRUGGER, WE ;
JURS, PC ;
ORNDORFF, MA ;
SNYDER, PJ ;
LOWRY, LD .
PHYSIOLOGY & BEHAVIOR, 1978, 20 (02) :175-185
[7]   INFLUENCE OF INTERTRIAL INTERVAL AND SNIFF-BOTTLE VOLUME ON PHENYL ETHYL-ALCOHOL ODOR DETECTION THRESHOLDS [J].
DOTY, RL ;
GREGOR, TP ;
SETTLE, RG .
CHEMICAL SENSES, 1986, 11 (02) :259-264
[8]   SMELL IDENTIFICATION ABILITY - CHANGES WITH AGE [J].
DOTY, RL ;
SHAMAN, P ;
APPLEBAUM, SL ;
GIBERSON, R ;
SIKSORSKI, L ;
ROSENBERG, L .
SCIENCE, 1984, 226 (4681) :1441-1443
[9]  
DOTY RL, 1986, DIS NERV SYST, P465
[10]   QUANTITATIVE PSYCHOPHYSICAL AND ELECTROPHYSIOLOGICAL DATA ON SOME ODOROUS COMPOUNDS [J].
DRAKE, B ;
JOHANSSO.B ;
VONSYDOW, E ;
DOVING, KB .
SCANDINAVIAN JOURNAL OF PSYCHOLOGY, 1969, 10 (02) :89-&