INHIBITION OF THE ACTIVATION OF HAGEMAN-FACTOR (FACTOR-XII) BY HUMAN VASCULAR ENDOTHELIAL-CELL CULTURE SUPERNATES

被引：12

作者：

RATNOFF, OD

EVERSON, B

EMBURY, P

ZIATS, NP

ANDERSON, JM

EMANUELSON, MM

MALEMUD, CJ

机构：

[1] CASE WESTERN RESERVE UNIV,SCH MED,INST PATHOL,CLEVELAND,OH 44106

[2] UNIV HOSP CLEVELAND,CLEVELAND,OH 44106

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 23期

关键词：

COAGULATION; THROMBOSIS;

D O I：

10.1073/pnas.88.23.10740

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The supernatant fluid (conditioned medium) of cultured human vascular endothelial cells inhibits activation of Hageman factor (factor XII), whether by ellagic acid, bovine brain sulfatides, or bismuth subgallate; inhibition appears to be a property of one or more proteins in the culture supernates. This phenomenon may contribute to maintaining the fluidity of circulating blood by inhibiting surface activation of the intrinsic pathway of coagulation.

引用

页码：10740 / 10743

页数：4

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