MELATONIN INDUCED INCREASE IN GAMMA-INTERFERON PRODUCTION BY MURINE SPLENOCYTES

被引:51
作者
COLOMBO, LL [1 ]
CHEN, GJ [1 ]
LOPEZ, MC [1 ]
WATSON, RR [1 ]
机构
[1] UNIV ARIZONA,ARIZONA HLTH SCI CTR,DEPT FAMILY & COMMUNITY MED,TUCSON,AZ 85724
关键词
MELATONIN; GAMMA-IFN; CIRCADIAN RHYTHM; PINEAL;
D O I
10.1016/0165-2478(92)90035-M
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Previously, we demonstrated that production of gamma-interferon (gamma-IFN) by the mouse splenocytes isolated at night was higher than from those isolated in the morning. In this paper we show that melatonin increased gamma-IFN production by murine splenocytes. Moreover, this stimulating effect was significantly higher (10 times) in the cells isolated at night than in those isolated in the morning (2 times).
引用
收藏
页码:123 / 126
页数:4
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