7-DAY ANTINOCICEPTIVE EFFECT OF A SUSTAINED-RELEASE VAPREOTIDE FORMULATION

被引：3

作者：

BETOIN, F

ESCHALIER, A

DUCHENEMARULLAZ, P

LAVARENNE, J

机构：

[1] Laboratoire de Pharmacologie Médicale, Equipe NPPA, Clermont-Ferrand Cedex

来源：

NEUROREPORT | 1994年 / 5卷 / 05期

关键词：

ANALGESIA; VAPREOTIDE; SOMATOSTATIN; RATS;

D O I：

10.1097/00001756-199401000-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THIS work studies the antinociceptive effect of a sustained (7 day) release dosage form of vapreotide, a peptidic analogue of somatostatin, in rats submitted to a nociceptive mechanical stimulus (paw pressure). One intramuscular injection (0.6 mg/animal) induced a significant antinociceptive effect for 7 complete days with a maximal increase in vocalization thresholds of 68 +/- 5% and a plateau of activity during the first 4 days. This action was totally inhibited by naloxone (1 mg kg(-1), s.c.) injected 24 h or 6 days after vapreotide, suggesting an opioidergic involvement throughout the antinociceptive effect. These findings suggest potential interest in human therapy.

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收藏

页码：642 / 644

页数：3

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