THE EFFECT OF RENAL IMPAIRMENT ON THE PHARMACOKINETICS AND METABOLISM OF BOPINDOLOL

被引:3
作者
MACDONALD, NJ
GRANT, AC
RODGER, RSC
MEREDITH, PA
ELLIOTT, HL
机构
[1] UNIV GLASGOW,STOBHILL GEN HOSP,DEPT MED & THERAPEUT,GLASGOW G21 3UW,SCOTLAND
[2] UNIV GLASGOW,STOBHILL GEN HOSP,RENAL UNIT,GLASGOW G21 3UW,SCOTLAND
关键词
BOPINDOLOL; CHRONIC RENAL FAILURE; PHARMACOKINETICS;
D O I
10.1111/j.1365-2125.1991.tb05596.x
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pharmacokinetics of the non-selective beta-adrenoceptor antagonist, bopindolol, have been studied in 18 hypertensive patients with varying degrees of renal impairment following single and multiple oral dosing. Bopindolol, which undergoes extensive hepatic metabolism, was found to accumulate in patients with chronic renal failure but the disposition in patients on regular haemodialysis did not differ significantly from patients with normal renal function. The mechanism underlying these changes in pharmacokinetics is not clear but suggests the presence of metabolic inhibitors in uraemic plasma which are removed by regular haemodialysis.
引用
收藏
页码:697 / 700
页数:4
相关论文
共 13 条
  • [1] RELATIONSHIP BETWEEN PLASMA-CONCENTRATIONS AND CARDIAC BETA-ADRENOCEPTOR BLOCKADE - A STUDY WITH ORAL AND INTRAVENOUS BOPINDOLOL
    AELLIG, WH
    NUESCH, E
    ENGEL, G
    GREVEL, J
    NIEDERBERGER, W
    ROSENTHALER, J
    [J]. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1986, 21 (01) : 45 - 51
  • [3] AHMED JH, 1991, IN PRESS BR J CLIN P
  • [4] ELIMINATION AND HEMODYNAMIC-EFFECTS OF NITRENDIPINE IN PATIENTS WITH CHRONIC RENAL-FAILURE
    ANKERMANN, T
    OSTERKAMP, U
    SANTOS, SR
    KIRCH, W
    [J]. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1989, 36 (05) : 433 - 437
  • [5] BERTHOLD R, 1981, BRIT J PHARMACOL, V74, pP829
  • [6] BIANCHETTI G, 1976, Clinical Pharmacokinetics, V1, P373, DOI 10.2165/00003088-197601050-00004
  • [7] FABRE J, 1986, J CARDIOVASC PHAR S6, V8, P450
  • [8] NIFEDIPINE - INFLUENCE OF RENAL-FUNCTION ON PHARMACOKINETIC HEMODYNAMIC RELATIONSHIP
    KLEINBLOESEM, CH
    VANBRUMMELEN, P
    VANHARTEN, J
    DANHOF, M
    BREIMER, DD
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1985, 37 (05) : 563 - 574
  • [9] SIMULTANEOUS MODELING OF BOPINDOLOL KINETICS AND DYNAMICS
    PLATZER, R
    GALEAZZI, RL
    NIEDERBERGER, W
    ROSENTHALER, J
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 1984, 36 (01) : 5 - 13
  • [10] ROSENTHALER J, 1982, RADIORECEPTOR ASSAY, P303