FAILURE OF A CHLORDIAZEPOXIDE TO REPRODUCE THE BEHAVIORAL-EFFECTS OF MUSCIMOL ADMINISTERED INTO THE BASAL FOREBRAIN

被引：19

作者：

DUDCHENKO, P ^{[1
]}

SARTER, M ^{[1
]}

机构：

[1] OHIO STATE UNIV,DEPT PSYCHOL,27 TOWNSHEND HALL,COLUMBUS,OH 43210

来源：

BEHAVIOURAL BRAIN RESEARCH | 1992年 / 47卷 / 02期

关键词：

GAMMA-AMINOBUTYRIC ACID; CHLORDIAZEPOXIDE; MUSCIMOL; BASAL FOREBRAIN; INTRACRANIAL INJECTION; CONDITIONAL DISCRIMINATION;

D O I：

10.1016/S0166-4328(05)80127-5

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Bilateral infusion of the GABA(A)-receptor agonist muscimol into the basal forebrain was previously found to impair visual conditional discrimination performance in rats. In order to examine whether the GABAergic input into the basal forebrain is active during performance of this task, the benzodiazepine receptor agonist chlordiazepoxide (15, 25, 40-mu-g/0.5-mu-l/hemisphere) was bilaterally infused. Surprisingly, chlordiazepoxide did not affect performance. The impact of this result for the understanding of basal forebrain GABAergic functions is discussed.

引用

页码：202 / 205

页数：4

共 17 条

[1]

BLAKER WD, 1985, BRAIN RES, V325, P389, DOI 10.1016/0006-8993(85)90347-6

[2] AMPHETAMINE LOWERS EXTRACELLULAR GABA CONCENTRATION IN THE VENTRAL PALLIDUM [J].

BOURDELAIS, A ;

KALIVAS, PW .

BRAIN RESEARCH, 1990, 516 (01) :132-136

[3] GABAERGIC CONTROL OF BASAL FOREBRAIN CHOLINERGIC NEURONS AND MEMORY [J].

DUDCHENKO, P ;

SARTER, M .

BEHAVIOURAL BRAIN RESEARCH, 1991, 42 (01) :33-41

[4]

HAEFELY WE, 1987, CHIMIA, V41, P389

[5]

HAEFELY WE, 1989, ALLOSTERIC MODULATIO, P47

[6] THE MAMMILLARY BODY IS A POTENTIAL SITE OF ANTIANXIETY ACTION OF BENZODIAZEPINES [J].

KATAOKA, Y ;

SHIBATA, K ;

GOMITA, Y ;

UEKI, S .

BRAIN RESEARCH, 1982, 241 (02) :374-377

[7]

Mishkin M., 1984, NEUROBIOLOGY LEARNIN, P65, DOI DOI 10.1523/JNEUROSCI.0840-16.2016

[8]

MORRIS RGM, 1984, NEUROBIOLOGY LEARNIN, P119

[9] ANTI-ANXIETY ACTION OF DIAZEPAM AFTER INTRA-AMYGDALOID APPLICATION IN THE RAT [J].

NAGY, J ;

ZAMBO, K ;

DECSI, L .

NEUROPHARMACOLOGY, 1979, 18 (06) :573-576

[10]

OLTON DS, IN PRESS BASAL FOREB

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