POSTSYNAPTIC CONTRIBUTION TO LONG-TERM POTENTIATION REVEALED BY THE ANALYSIS OF MINIATURE SYNAPTIC CURRENTS

被引：308

作者：

MANABE, T

RENNER, P

NICOLL, RA

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACOL,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

来源：

NATURE | 1992年 / 355卷 / 6355期

关键词：

D O I：

10.1038/355050a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Miniature excitatory synaptic currents were recorded from CA1 pyramidal cells in hippocampal slices to study the site of the persistent change in synaptic efficacy during long-term potentiation. Induction of long-term potentiation produced a large increase in the amplitude of these currents. Such a change in amplitude suggests an increase in postsynaptic transmitter sensitivity.

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页码：50 / 55

页数：6

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